Precision Laboratory Programmable Syringe Pump - LSPone | AMF

LSPone – Laboratory Programmable Syringe Pump

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The LSPone – Laboratory Microfluidic Programmable Syringe Pump is a high-precision dosing system designed as a benchtop for automated microfluidic academic research applications. The LSPone is the unique combination of a high-precision syringe pump with a low-volume rotary valve. This unique device coupled with the intuitive LSPoneQuick software can aspirate or dispense liquids, automate fluid handling, multiplex your experiment, control the flow rate, prepare complex mixes, or dilute samples or reagents.

The ALL-IN-ONE Laboratory Microfluidic Programmable Syringe Pump

AMF’s LSPone is suited for microfluidic automation, by design. The optimized space between the rotary valve and the syringe dramatically reduces the internal volume of the module and leads to optimized carryover volumes. The LSPone offers an optimal flow rate, proficiently diluting samples or reagents from milliliters down to nanoliters. It aspirates or dispenses liquids, controls the flow rate, and prepares complex mixes. This versatile tool can efficiently switch between air and liquid samples, ensuring no leakage due to its superior sealing capabilities.

Plug-and-Play benchtop solution to automate your microfluidic experiment:

  • Wetted Material: The rotary valve’s wetted material is PCTFE (for the valve head), PTFE (valve rotor) and borosilicate glass (for the syringe) ensuring robustness and broad chemical compatibility.
  • Channel Diameter: 500 µm to 1000 µm. The conjunction of small internal channel size with unique AMF geometry allows it to reach extremely low internal volumes which can go as low as 600 nL*. This particular attribute optimizes your operation time, saves material (reagents, test materials and samples) and leads ultimately to reduced cost of operations for your final microfluidic application or instrument.
  • Number of Ports: up to 12 radial ports. The valve’s number of ports will give you the ability to handle multiple fluids (from 6 to 12) within your microfluidic device (or detection chamber) and/or manipulate multiple fluids (sample to be tested, reagents, gases).
  • Syringe volume: 500 µL to 1000 µL. Our high-precision syringes are made of borosilicate glass while the plunger is made of PTFE, making our device compatible with biological samples and a wide range of chemicals.

Advanced Microfluidics unique microfluidic LSPone design:


  • Integrated sensor: the position sensor is directly integrated into the valve rotor (2) to ensure precise valve positioning and internal channel alignment between the rotor and the stator (2). An automatic procedure at power-up alerts the valve of its precise location.
  • For your motor, choose between the fast model for a port switching speed as low as 150 ms and the low power model to reduce power consumption for better portable device integration and smaller power supply.
  • Ready to use: the LSPone is designed for seamless integration, making it incredibly user-friendly. It comes complete with a USB cable & power supply (5), and intuitive software, ensuring hassle-free setup and operation.
  • High precision syringe pump (3)

Advanced Microfluidics unique LSPoneQuick Software:


  • The LSPoneQuick allows for seamless control of the LSPone. Its ease of use and simplicity allows you to unleash the full potential of the LSPone for your microfluidic experiment in seconds.
  • We integrated an intuitive script editor that allows you to automate the LSPone functions.


*Our unique precise valves exhibit an internal volume (port-to-port) down to 600 nL (for a 4 ports switch valves) due to their exceptionally small 0.25 mm diameter channels.

More details

Application and technical notes

Enhance your expertise with our Application Notes, focused on microfluidic technology utilization:

Use two simultaneous flow with two LSPone syringe pump for microfluidic droplet generation within a chip.

Learn the technique of rapid prototyping for microfabrication and test the fabrication by observing the flow of 2 liquids using optical microscopy.

Automatic cell culture media management system with microfluidic distribution valves and laboratory syringe pump


Gain further insights with detailed guides on:

For comprehensive information, visit our technical notes page.

Discover how our LSPone syringe pump is advancing research across various fields. Explore the most recent publications where the LSPone’s precision and reliability have been pivotal:

Xiaokang Li, Hui Song Pak, Florian Huber, Justine Michaux, Marie Taillandier-Coindard, Emma Ricart Altimiras, Michal Bassani-Sternberg – A microfluidics-enabled automated workflow of sample preparation for MS-based immunopeptidomics – Cell Reports Methods – Volume 3, Issue 6 – 2023 – 100479 – ISSN 2667-2375

Maël Arveiler, Stephanie Ognier, Olivier Venier, Laurent Schiob and Michael Tatoulian – An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures – Reaction Chemistry & Engineering – Issue 11, 2023

Christian Thoben, Nora T. Hartner, Moritz Hitzemann, Christian-Robert Raddatz, Manuel Eckermann, Detlev Belder, and Stefan Zimmermann – Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS – Journal of the American Society for Mass Spectrometry 2023 34 (5), 857-868

Ortiz-Perez A, van Tilborg D, van der Meel R, Grisoni F, Albertazzi L. – Machine learning-guided high throughput nanoparticle design – ChemRxiv. 2023

For more comprehensive details or to explore older publications featuring our LSPone, please don’t hesitate to contact us.

For more detailed information, firmware, maintenance or software visit our Documentations & Downloads page.

Pump specifications

Description Specification
Operating temperature 15 – 40°C (59-104°F)
Operating humidity 20-80%, non condensing
Max. pressure 7 bars (102 psi)
Wetted materials PTFE, PCTFE and borosilicate glass
Dead volume None
Carryover volume 1.5 – 10.2 μL
Plunger travel 30 mm with 96,000 micro-steps for nearly pulseless flow
Plunger resolution Selectable 3,000 steps (standard) / 24,000 steps (high)
Plunger drive Screw drive with linear encoder for step loss detection
Valves configuration Zero-dead-volume multi-port distribution with angular encoder
Tube port fittings Standard 1/4 – 28 UNF, flat-bottom
Cross-contamination Typically from 1/100 to 1/1000 per cleaning cycle
Accuracy < 1% deviation from expected value at full stroke
Electrical interface USB mini, 9–pin D–Sub (other upon request)
Interface USB mini, RS-232, RS-485
Communication type Serial (serial over USB, RS232, RS485)
Power 18 - 24 VDC, 2.2 A peak, 40 W / 18 VDC optimized for battery use
Time for full stroke 2 to 6000 seconds
Dimensions 245 x 143 x 85 mm
Weight 2.2 kg
Graphical user interface MS Windows 7 and later vers.
Certifications CE and CB certified

Valve specifications

Ref. Configuration Wetted materials Internal volume Carryover volume Fluid path diameter Maximum pressure
V-D-2-6-050-C-P 6 ports ultra-low carryover volume PCTFE, PTFE 5.2 μL 1.5 μL 0.5 mm 7 bars
V-D-1-6-050-C-P 6 ports low carryover volume PCTFE, PTFE 3.5 μL 2.6 μL 0.5 mm 7 bars
V-D-1-8-050-C-P 8 ports low carryover volume PCTFE, PTFE 3.5 μL 2.6 μL 0.5 mm 7 bars
V-D-1-8-100-C-P or U 8 ports low carryover volume PCTFE, PTFE or UHMW-PE 14.1 μL 10.2 μL 1 mm 7 bars
V-D-1-10-050-C-P or U 10 ports low carryover volume PCTFE, PTFE or UHMW-PE 4.5 μL 2.8 μL 0.5 mm 7 bars
V-D-1-10-100-C-P or U 10 ports low carryover volume PCTFE, PTFE or UHMW-PE 18.1 μL 11 μL 1 mm 7 bars
V-D-1-12-050-C-P or U 12 ports low carryover volume PCTFE, PTFE or UHMW-PE 4.5 μL 2.8 μL 0.5 mm 7 bars

Other configurations are available upon request.

Syringe specifications

Ref. Volume Plunger material Minimum flow rate Maximum flow rate Minimum dosing volume
S-50-P 50 μL PTFE 0.5 μL/min 1500 μL/min 0.1 μL
S-100-P 100 μL PTFE 1 μL/min 3000 μL/min 0.2 μL
S-250-P 250 μL PTFE 2.5 μL/min 8000 μL/min 0.5 μL
S-500-P or S-500-U 500 μL PTFE or UHMW-PE 5 μL/min 15,000 μL/min 1 μL
S-1000-P 1000 μL PTFE 10 μL/min 30,000 μL/min 2 μL

Chemical compatibility: The wetted materials being PTFE, PCTFE and borosilicate glass, this pump offers exceptional compatibility with most chemicals and biological samples.

LSPone Pump automates nanoparticle formulation and imaging

Ana Ortiz Perez - PhD TUe (Eindhoven)

LSPone aids publications via easy programming and clear manuals

Gilles Ouderbrouckx - Researcher Hasselt University

LSPone excels in aspiration, mixing, and slow-flow setups

Jenny Maner - PhD Student Eawag

The LSPone pumps perfectly fit our application requirements

Robert Toner - Lead Engineer Sarepta Therapeutics

Custom AMF components allowed us to develop the first online flow cytometer for water monitoring

Simon Kuenzi - CEO bNovate

AMF’s products automate microfluidics with precise control and timely support

Xiaokang LI - Postdoctoral researcher Department of Oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne Centre de recherche Agora

AMF valves, delicately designed, reflect Swiss precision

Yujing Song - PhD Michigan Univeristy

FAQ: Exploring the LSPone - Laboratory Programmable Syringe Pump

Navigate through our comprehensive FAQ section to gain a deeper understanding of the LSPone Laboratory Microfluidic Programmable Syringe Pump – a pivotal tool in advancing microfluidic research. The LSPone combines high-precision fluid handling with user-friendly automation, making it an essential device for modern laboratories. Here, we address your queries about its functionalities, integration capabilities, and innovative software. Discover how the LSPone’s versatility and precision can revolutionize your lab workflows, whether in academic research or industrial applications. Our FAQs provide insights to fully leverage the potential of the LSPone in enhancing your scientific endeavors.

The LSPone serves as an all-in-one microfluidic syringe pump, automating laboratory workflows with its high-precision dosing and versatile fluid handling capabilities. It can manage tasks like aspirating or dispensing liquids, controlling flow rates, and preparing complex mixes. With the intuitive LSPoneQuick software, users can easily program the pump for a variety of tasks, ensuring efficient and accurate automation of microfluidic experiments. This software enhances the user experience by simplifying complex procedures, allowing for programmable sequences and precise control, making the LSPone a cornerstone in modernizing and automating laboratory processes.

The LSPone syringe pump has no dead volume, ensuring efficient fluid handling in microfluidic applications. This feature is crucial for precision in academic research, where accurate dosing and minimal waste are key. The absence of dead volume enhances the pump’s efficiency, making it a reliable tool in various scientific applications where accurate and consistent fluid control is required.

The LSPone’s carryover volume ranges from 1.5 to 10.2 µL, depending on the configuration. This optimized carryover volume is essential for reducing cross-contamination and ensuring sample integrity in microfluidic experiments. The design focuses on precise fluid control, contributing to the pump’s effectiveness in applications where minimizing sample contamination is critical.

The LSPone features an extremely low internal volume, potentially as low as 600 nL. This low internal volume is significant in applications requiring precision and reduced material usage. It optimizes operation time and saves materials, making the LSPone efficient for high-precision fluid handling in various scientific applications.

The LSPone integrates seamlessly with existing microfluidic systems. Its design allows it to handle multiple fluids and control flow rates precisely, making it ideal for lab-on-a-chip applications and complex microfluidic setups. The pump’s user-friendly interface and customizable settings facilitate integration into various scientific environments.

The average lead time for the LSPone syringe pump is approximately 4 weeks, although this may vary based on configuration. This efficient lead time aligns with the requirements of fast-paced microfluidic research and industrial applications, ensuring swift integration into laboratory settings.

The LSPone uses PCTFE, PTFE, and borosilicate glass in its wetted parts, offering broad chemical compatibility and robustness. These materials make the pump suitable for handling a wide range of chemicals and biological samples, enhancing its versatility across different applications.

The LSPone features a plunger with 96,000 micro-steps for nearly pulseless flow and precise fluid control. This high precision is crucial for applications requiring accurate fluid dispensing and minimal flow rate variation, making the LSPone a key tool in precision microfluidics.

The LSPone offers a versatile electrical interface, including USB mini and 9-pin D-Sub, supporting various communication types such as Serial. This versatility in connectivity facilitates easy integration with different control systems, enhancing its usability in microfluidic setups.

The LSPone is designed with standard 1/4 – 28 UNF, flat-bottom tube port fittings, ensuring compatibility with a wide range of tubing types. This feature allows for easy integration with existing microfluidic systems and flexible setup configurations.

The LSPone syringe pump requires 18 – 24 VDC, with a peak current of 2.2 A and a power consumption of 40 W, optimized for battery use. These power specifications ensure that the pump can be used efficiently in various laboratory settings, including those requiring portable or battery-operated devices. The power efficiency of the LSPone, combined with its precision and versatility, makes it ideal for a wide range of applications, from regular laboratory use to more specialized scientific experiments where reliable and continuous fluid delivery is essential.

The LSPone offers optimal flow rate control, efficiently handling fluids from milliliters to nanoliters. This precise control is essential in applications requiring accurate dilution and dispensing of samples or reagents, making the LSPone an invaluable tool in microfluidic applications.

The LSPone operates efficiently within a temperature range of 15 – 40°C (59-104°F). This range ensures stable performance under various laboratory conditions, making it suitable for a wide array of scientific applications.

The LSPone is designed to handle a maximum pressure of 7 bars (102 psi), making it suitable for a variety of high-pressure microfluidic applications. This capability allows it to operate efficiently under varying pressure conditions, ensuring consistent performance and reliability.

The LSPone pump maintains an accuracy of less than 1% deviation from the expected value at full stroke, ensuring precise and reliable dosing in microfluidic applications. This level of accuracy is crucial for scientific experiments where precision in fluid handling can significantly impact the results.

They trust us

From top-tier academic institutions to pioneering biotech companies, Advanced Microfluidics is the preferred partner for innovative microfluidic solutions. Our track record of excellence and precision has earned us the trust of industry leaders, driving us to push boundaries and redefine possibilities together.

Made in Switzerland
10+ years of experience
Short Lead Time