Revolutionizing Chemical Processes
AMF Website NEWS-Chemistry
Nov 2023

Revolutionizing Chemical Processes: A New Era of Sequential Flow Strategy

We extend our heartfelt congratulations to Maël Arveiler and his team for their groundbreaking work in chemical engineering. Their recent study demonstrates an innovative approach to multi-step chemical processes, marking a significant progress in the field of flow chemistry.

Unraveling the Sequential Flow Strategy

AMF - Mael Arveiller - Revolutionizing Chemical Processes - A New Era of Sequential Flow Strategy
The research presented a groundbreaking ‘sequential flow strategy,’ in contrast to traditional in-line continuous flow methods. This innovative strategy simplifies the execution of complex multi-step chemical reactions, making it more efficient and manageable. The essence of the experiment was the successful separation of a mixture of amine and alkene, a task that involved intricate procedures such as biphasic liquid-liquid extractions and acid-alkali transformations.

What sets this approach apart is its ability to decouple the steps involved in multi-step reactions, allowing for more control and flexibility. Each phase of the process can be optimized independently, leading to greater efficiency and precision. The use of a compact, automated micro-lab platform was pivotal, providing a minimal spatial footprint while maintaining versatility in handling a diverse range of chemical processes.

This novel technology revolutionizes several sectors. In the pharmaceutical industry, it speeds up drug development, allowing for quicker synthesis and testing of new compounds. In materials science, it aids in creating advanced materials for use in diverse industries. Importantly, it also champions sustainable chemistry by reducing waste and energy use, aligning with green chemistry principles and promoting environmentally friendly practices.

The automation aspect can significantly reduce human error, enhancing reproducibility and scalability in chemical research. This is especially beneficial in industries where consistency and quality control are paramount.

Advanced Microfluidics (AMF) Technology Enables Automating Complex Chemical Processes

AMF - Mael Arveiller - Revolutionizing Chemical Processes - A New Era of Sequential Flow Strategy - AMF 1

In this innovative experiment, AMF technology played a significant role with the utilization of AMF LSPone (actually in the experiment, they used 2 SPM – Industrial Programmable Syringe Pump) as well as two distribution 8-ports rotary valves (RVMFS – Industrial Microfluidic Rotary Valve). The unmet low internal volume and optimized carryover volume* provided precise control and automation of fluid dispensing, a key requirement for implementing the sequential flow strategy effectively.

The standout feature of AMF technology in this context is its emphasis on automation, which is crucial for ensuring consistent and accurate results in complex chemical processes. The automation provided by these micro-dispensers and distribution valves (RVM – Industrial Microfluidics Rotary Valve) minimizes manual interventions, thereby reducing errors and enhancing the repeatability of experiments. It also contributes to the overall efficiency and speed of the chemical process.

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Another essential aspect of the AMF systems is their low internal volume. This attribute is particularly advantageous in chemical synthesis as it leads to reduced reagent usage, less waste, and increased safety by limiting the exposure to potentially hazardous materials. Additionally, the design of these AMF components effectively eliminates dead volumes, a critical factor in processes where precise reagent volumes are crucial. The elimination of dead volumes not only conserves valuable chemicals but also prevents cross-contamination between steps, ensuring the integrity and purity of the synthesized products.

In summary, the use of AMF technology in the experiment, characterized by its automation, low internal volume, and absence of dead volumes, contributed to the efficient and precise execution of complex chemical processes.

Elevating Your Research with AMF Technology

AMF technology, as demonstrated in this groundbreaking research, offers immense possibilities for scientists and researchers. Its precision in fluid control and automation makes it an invaluable tool for executing complex multi-step chemical processes. Whether it’s in drug discovery, material science, or synthetic chemistry, AMF technology can significantly enhance the efficiency and accuracy of experiments. By simplifying the setup and automating repetitive tasks, it allows researchers to focus on innovation and exploration.

Explore the Depths of Chemical Engineering Innovations

For those intrigued by this approach in chemical processing and eager to delve deeper into the technical setup, further details and insights are available. The full research paper offers a comprehensive look at the methodologies, challenges, and solutions involved in this significant breakthrough. It’s an invaluable resource for anyone looking to expand their understanding of modern chemical engineering and the transformative potential of AMF technology.

Read the publication

* An optimized carryover volume is critical in microfluidics for reducing cross-contamination and ensuring the integrity of sequential sample handling. The design of the SPM, focusing on precise fluid control, contributes to its effectiveness in applications where minimizing sample contamination is essential​​.

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