Laboratory Programmable Syringe Pumps - LSPone Series
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From 6 to 12 ports valve integrated

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From 50 µL to 5 mL capacity

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PTFE / PCTFE

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Stand alone / Ready to use

LSPone series – Laboratory Programmable Syringe Pumps

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    Summary

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The LSPone series delivers high-precision, programmable syringe pumps with a low-volume rotary valve engineered for demanding laboratory and pre-industrial applications. Our range includes the LSPone, LSPone+, LSPone HD, and LSPone+ HD models, all designed to automate fluid handling, multiplex your experiment, control the flow rate, prepare complex mixes, or dilute samples or reagents with advanced programming and intuitive LSPoneQuick software.

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The ALL-IN-ONE Laboratory Microfluidic Programmable Syringe Pump

The LSPone series integrates a high-precision syringe pump with a low-volume rotary valve to minimize internal dead volume (as low as 600 nL) and ensure linear, consistent liquid delivery. Engineered for applications ranging from microfluidic research to industrial chemical processes, these pumps provide precise flow control with ultra-low flow rates (down to 7,45 nL/min) and are built for reliability. They offer a robust design using high-quality materials that ensure long-term performance even in harsh chemical environments.

Key benefits include accurate flow control, flexible programming, and a construction that delivers both precision and durability.

LSPone series

The LSPone series is available in several variants to address specific application needs:

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LSPone: P100-L

Ideal for low-volume applications with syringe capacities between 50 µL and 1 mL. Perfect for academic research, proof-of-concept experiments, and prototype development.

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LSPone+: P101-L

Expands capabilities with larger syringe options (2,5 mL and 5 mL), enabling extended experiments and higher-volume processes.

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LSPone HD / LSPone+ HD: P110-L / P111-L

Designed for pulseless operation at ultra low-flow rates. The redesigned LSPone with some hardware modifications increases resolution and ensures smooth, continuous delivery even at flow rates as low as 7,45 nL/min. Available in June 2025

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LSPone: P100-L

Ideal for low-volume applications with syringe capacities between 50 µL and 1 mL. Perfect for academic research, proof-of-concept experiments, and prototype development.

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LSPone+: P101-L

Expands capabilities with larger syringe options (2,5 mL and 5 mL), enabling extended experiments and higher-volume processes.

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LSPone HD / LSPone+ HD: P110-L / P111-L

Designed for pulseless operation at ultra low-flow rates. The redesigned LSPone with some hardware modifications increases resolution and ensures smooth, continuous delivery even at flow rates as low as 7,45 nL/min. Available in June 2025

All models share a common design philosophy that emphasizes precision, ease of integration, and robust performance.

Plug-and-Play benchtop solution to automate your microfluidic experiment

The design of the LSPone series is focused on high performance and versatility. Below are detailed specifications for our pumps:

  • Syringe volume options:
    • LSPone: 50 µL to 1 mL, ideal for precise, low-volume applications
    • LSPone+: Offers expanded options with syringes up to 2,5 mL and 5 mL (5000 µL) for extended fluid delivery, ideal for continuous infusion
  • Flow rate capabilities:
    • Ultra-low flow rates achievable down to 7,45 nL/min for highly sensitive applications
    • HD model: achieving pulseless, linear operation at ultra-low flow rates
    • Configurable for higher flow rates when rapid infusion or withdrawal
  • Internal volume and design:
    • Optimized channel design minimizes internal dead volume to as low as 600 nL*
    • Channel diameters range between 500 µm and 1000 µm, ensuring minimal reagent waste
    • No dead volume for almost non-existent cross contamination
  • Rotary valve features:
    • Equipped with up to 12 radial ports, enabling simultaneous management of multiple fluid channels.
    • Low-volume rotary valve design enhances mixing capabilities and reduces cross-contamination.
  • Materials:
    • The rotary valve’s wetted material is PCTFE (for the valve head), PTFE (valve rotor) and borosilicate glass (for the syringe) ensuring robustness and broad chemical compatibility.
  • Environmental & electrical specifications:
    • Designed for stable operation over a wide range of ambient temperatures.
    • Low power consumption options available, optimizing energy use in continuous operations.
    • Integrated fault detection with real-time monitoring of flow rate, volume, and motor status.

These technical details ensure that the LSPone series provides both the precision and flexibility required for the most demanding fluid handling tasks.

Advanced Microfluidics unique microfluidic LSPone design

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Every LSPone model is built with precision and seamless integration in mind. Our design features:

  • Integrated sensor: the position sensor is directly integrated into the valve rotor (2) to ensure precise valve positioning and internal channel alignment between the rotor and the stator (2). An automatic procedure at power-up alerts the valve of its precise location.
  • Fast motor capable of switching ports in as little as 150 ms, ensuring rapid response during dynamic experiments
  • Ready to use: the LSPone is designed for seamless integration, making it incredibly user-friendly. It comes complete with a USB cable & power supply (5), and intuitive software (LSPoneQuick), ensuring hassle-free setup and operation.
  • High precision syringe pump (3)

Advanced Microfluidics unique LSPoneQuick software: Advanced programming & control

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The LSPoneQuick software provides comprehensive control through an intuitive interface. Engineers can easily set exact dispensing volumes and program both infusion and withdrawal cycles. We integrated an intuitive script editor that allows you to automate the LSPone functions: write your custom programs that allow the insertion of pauses, gradient ramping, etc. ensuring consistent flow rates even during complex sequences.

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Additionally, program memory enables storage of multiple protocols for various applications, and the system integrates ideally with external controllers and sensors to adjust parameters in real time.

Applications

The LSPone series is designed for scenarios where precise fluid control is essential. It finds use in a variety of critical applications, including:

  • Microfluidic research: Automation of lab-on-a-chip devices, cellular assays, and other microfluidic setups that require accurate, low-volume fluid handling.
  • Pharmaceutical testing: Supports controlled drug infusion and withdrawal, which is vital for pharmacokinetic studies.
  • Chemical analysis: Enables precise reagent mixing and dilution, ensuring accuracy and reproducibility in analytical chemistry.
  • Automated fluid handling: Seamlessly integrates with laboratory automation systems for continuous, high-throughput operation.
  • Infusion and withdrawal processes: Capable of both infusing and withdrawing fluids, offering flexible control for diverse experimental protocols.

For even more specialized needs, consider applications such as:

  • Droplets generation: Produces uniform droplets for applications such as digital PCR, single-cell analysis, and droplet-based assays.
  • Protein isolation: Facilitates efficient extraction and isolation of proteins for downstream biochemical and proteomic analyses.
  • Cell culture media management system: Provides automated control of cell culture media delivery, maintaining optimal conditions for bioreactor and culture system operations.
  • Continuous biosensing: Ensures stable and consistent fluid delivery for long-term biosensing applications.
  • Ion mobility spectrometry: Offers precise sample injections and controlled fluid handling for ion mobility spectrometry analyses.
  • Immunopeptidomics: Supports sample preparation workflows for immunopeptidomics, enabling efficient extraction and processing of peptides.
  • Sequential flow strategy: Facilitates the sequential introduction of reagents and buffers, which is ideal for multi-step reactions and protocols.
  • Nanoparticle formulation: Enables accurate mixing and formulation of nanoparticles, ensuring uniformity and reproducibility in nanomaterial synthesis.

Whatever your experiment, whether you need a robust sample preparator, the ability to multiplex, or full automation of your workflow, the LSPone series is the perfect tool. It allows you to quickly validate your proof of concept and seamlessly transition to prototyping and industrial-scale production, meeting even the most demanding requirements in research and development.

*Our unique precise valves exhibit an internal volume (port-to-port) down to 600 nL (for a 4 ports switch valves) due to their exceptionally small 0.25 mm diameter channels.

More details

Application and technical notes

Enhance your expertise with our Application Notes, focused on microfluidic technology utilization:

Use two simultaneous flow with two LSPone syringe pump for microfluidic droplet generation within a chip.

Learn the technique of rapid prototyping for microfabrication and test the fabrication by observing the flow of 2 liquids using optical microscopy.

Automatic cell culture media management system with microfluidic distribution valves and laboratory syringe pump

 

Gain further insights with detailed guides on:

For comprehensive information, visit our technical notes page.

Discover how our LSPone syringe pump is advancing research across various fields. Explore the most recent publications where the LSPone’s precision and reliability have been pivotal:

Xiaokang Li, Hui Song Pak, Florian Huber, Justine Michaux, Marie Taillandier-Coindard, Emma Ricart Altimiras, Michal Bassani-Sternberg – A microfluidics-enabled automated workflow of sample preparation for MS-based immunopeptidomics – Cell Reports Methods – Volume 3, Issue 6 – 2023 – 100479 – ISSN 2667-2375

Maël Arveiler, Stephanie Ognier, Olivier Venier, Laurent Schiob and Michael Tatoulian – An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures – Reaction Chemistry & Engineering – Issue 11, 2023

Christian Thoben, Nora T. Hartner, Moritz Hitzemann, Christian-Robert Raddatz, Manuel Eckermann, Detlev Belder, and Stefan Zimmermann – Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS – Journal of the American Society for Mass Spectrometry 2023 34 (5), 857-868

Ortiz-Perez A, van Tilborg D, van der Meel R, Grisoni F, Albertazzi L. – Machine learning-guided high throughput nanoparticle design – ChemRxiv. 2023

For more comprehensive details or to explore older publications featuring our LSPone, please don’t hesitate to contact us.

For more detailed information, firmware, maintenance or software visit our Documentations & Downloads page.

LSPone P100-L & LSPone HD P110-L – (50 µL to 1 mL syringe size)

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LSPone+ P101-L & LSPone+ HD P111-L (2.5 mL & 5 mL syringe size)

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Pump specifications

Description Specification:
LSPone P100-L & LSPone HD P110-L		 Specification:
LSPone P101-L & LSPone HD P111-L
Operating temperature 15 – 40°C (59-104°F) 15 – 40°C (59-104°F)
Operating humidity 20-80%, non condensing 20-80%, non condensing
Max. pressure 7 bars (102 psi) 7 bars (102 psi)
Wetted materials PTFE, PCTFE and borosilicate glass PTFE, PCTFE and borosilicate glass
Dead volume None None
Carryover volume 1.5 – 10.2 μL 18.1 – 34 μL
Plunger travel 30 mm with 96,000 micro-steps for nearly pulseless flow 30 mm with 96,000 micro-steps for nearly pulseless flow
Plunger resolution Selectable 3,000 steps (standard) / 24,000 steps (high) Selectable 3,000 steps (standard) / 24,000 steps (high)
Plunger drive Screw drive with linear encoder for step loss detection Screw drive with linear encoder for step loss detection
Valves configuration Zero-dead-volume multi-port distribution with angular encoder Zero-dead-volume multi-port distribution with angular encoder
Tube port fittings Standard 1/4 – 28 UNF, flat-bottom Standard 1/4 – 28 UNF, flat-bottom
Cross-contamination Typically from 1/100 to 1/1000 per cleaning cycle Typically from 1/100 to 1/1000 per cleaning cycle
Accuracy < 1% deviation from expected value at full stroke < 1% deviation from expected value at full stroke
Electrical interface USB mini, 9–pin D–Sub (other upon request) USB mini, 9–pin D–Sub (other upon request)
Interface USB mini, RS-232, RS-485 USB mini, RS-232, RS-485
Communication type Serial (serial over USB, RS232, RS485) Serial (serial over USB, RS232, RS485)
Power 18 - 24 VDC, 2.2 A peak, 40 W / 18 VDC optimized for battery use 18 - 24 VDC, 2.2 A peak, 40 W / 18 VDC optimized for battery use
Time for full stroke 2 to 6000 seconds 2 to 6000 seconds
Dimensions 247 x 147 x 85 mm 260 x 146 x 85 mm
Weight 2.2 kg (P100-L) & 2.3kg (P110-L) 2.2 kg (P101-L) & 2.3kg (P111-L)
Graphical user interface MS Windows 7 and later vers. MS Windows 7 and later vers.
Certifications CE and CB certified CE and CB certified

Valve specifications for P100-L & P110-L

Ref. Configuration Wetted materials Internal volume Carryover volume Fluid path diameter Maximum pressure
V-D-2-6-050-C-P 6 ports ultra-low carryover volume PCTFE, PTFE 5.2 μL 1.5 μL 0.5 mm 7 bars
V-D-1-6-050-C-P 6 ports low carryover volume PCTFE, PTFE 3.6 μL 2.6 μL 0.5 mm 7 bars
V-D-1-8-050-C-P 8 ports low carryover volume PCTFE, PTFE 3.6 μL 2.6 μL 0.5 mm 7 bars
V-D-1-8-100-C-P or U 8 ports low carryover volume PCTFE, PTFE or UHMW-PE 14.9 μL 7.8 μL 1 mm 7 bars
V-D-1-10-050-C-P or U 10 ports low carryover volume PCTFE, PTFE or UHMW-PE 4.6 μL 2.8 μL 0.5 mm 7 bars
V-D-1-10-100-C-P or U 10 ports low carryover volume PCTFE, PTFE or UHMW-PE 14.9 μL 7.8 μL 1 mm 7 bars
V-D-1-12-050-C-P or U 12 ports low carryover volume PCTFE, PTFE or UHMW-PE 4.6 μL 2.8 μL 0.5 mm 7 bars

Valve specifications for P101-L & P111-L

Ref. Configuration Wetted materials Internal volume Carryover volume Fluid path diameter Maximum pressure
V-D-1-12-050-C-P 12 ports low carryover volume PCTFE, PTFE 15.4 μL 13.6 μL 0.5 mm 7 bars

Other configurations are available upon request.

Syringe specifications

Ref. Volume Plunger material Minimum flow rate Maximum flow rate Minimum dosing volume
S-50-P 50 μL PTFE 0.00745 μL/min 1 500 μL/min 0.1 μL
S-100-P 100 μL PTFE 0.0149 μL/min 3 000 μL/min 0.2 μL
S-250-P 250 μL PTFE 0.03725 μL/min 8 000 μL/min 0.5 μL
S-500-P or S-500-U 500 μL PTFE or UHMW-PE 0.0745 μL/min 15 000 μL/min 1 μL
S-1000-P 1000 μL PTFE 0.149 μL/min 30 000 μL/min 2 μL
S-2500-P 2.5 mL PTFE 0.3725 µL/min 75 000 µL/min 5 µL
S-5000-P 5 mL PTFE 0.745 µL/min 150 000 µL/min 10 µL

Chemical compatibility: The wetted materials being PTFE, PCTFE and borosilicate glass, this pump offers exceptional compatibility with most chemicals and biological samples.

The above specifications are typical for our components and may vary due to multiple parameters / factors (e.g. fluid type, usage conditions…). Specifications are subject to change.

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LSPone Pump automates nanoparticle formulation and imaging

Ana Ortiz Perez - PhD TUe (Eindhoven)

LSPone aids publications via easy programming and clear manuals

Gilles Ouderbrouckx - Researcher Hasselt University

LSPone excels in aspiration, mixing, and slow-flow setups

Jenny Maner - PhD Student Eawag

The LSPone pumps perfectly fit our application requirements

Robert Toner - Lead Engineer Sarepta Therapeutics

Custom AMF components allowed us to develop the first online flow cytometer for water monitoring

Simon Kuenzi - CEO bNovate

AMF’s products automate microfluidics with precise control and timely support

Xiaokang LI - Postdoctoral researcher Department of Oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne Centre de recherche Agora

AMF valves, delicately designed, reflect Swiss precision

Yujing Song - PhD Michigan Univeristy

FAQ: Exploring the LSPone

A programmable syringe pump is part of the family of laboratory syringe pumps. It’s a precision instrument designed to infuse (aspire), withdraw (dispense) fluids with exact control. These pumps, part of our LSPone series of syringe solutions, deliver smooth, scientific legato fluid handling. They are designed for various applications and provide selectable, linear pumping profiles that let you set both minimum and maximum flow rates with ease.

Our pumps are specifically engineered for microfluidic research. They handle small volumes with precise control, making them ideal for lab-on-a-chip devices and cellular assays. With dual functionality for both infusion (push) and withdrawal (pull), these pumps operate in a compact size while delivering consistent performance, ensuring minimal cross-contamination and reliable pressure control.

Programming is straightforward with our LSPoneQuick software. Using the intuitive software, you can easily set dispensing volumes, insert pauses, rotate the valve and change pumping profiles. The software offers extra functions such as gradient ramping and supports external signals, so you can adjust parameters in real time. This easy, selectable interface lets you modify both push and pull operations, making your programming as dynamic as your experiment.

Our pumps are engineered to deliver ultra-low flow rates down to 7,45 nL/min while also being configurable for high pumping speeds up to around 30,000 µL/min. This broad range ensures that you achieve accurate liquid delivery, whether you need a minimal rate for long-term scientific studies or a maximum flow rate for rapid infusion or withdrawal.

The LSPone series offers multiple syringe options. The standard LSPone models provide capacities between 50 µL and 1 mL—ideal for low-volume, high-precision tasks. For higher-volume applications, the LSPone+ models support syringes up to 2,5 mL and 5 mL (5000 µL), ensuring flexibility without the need for extra refills or separately sold syringes.

Selecting the right model depends on factors like the required syringe size, flow rate, and specific application type or function. For low-volume, proof-of-concept experiments, the LSPone (P100-L) is ideal. For higher-volume processes or continuous infusion, consider the LSPone+ (P101-L) or the high-definition models (P110-L/P111-L) that offer pulseless, linear operation at ultra-low flow rate. Our experts can guide you on the best type all at a competitive price suited for a budget minded lab.

Key features include a syringe pump (with a syringe from 50 µL to 5 mL), a low-volume distribution rotary valve that removes dead volume and minimizes internal volume (as low as 600 nL) from 6 to 12 ports, and advanced programming via LSPoneQuick. Our pumps offer a high precision linear force with an attached sensor for exact valve positioning. They are built with robust, ROHS-compliant materials and provide selectable syringe sizes and voltage options, making them ideal for various applications and high-accuracy scientific work.

LSPoneQuick provides a comprehensive suite of programming functions. You can set exact dispensing volumes, insert pauses, rotate the valve and adjust pumping rates to change pumping profiles. The software allows you to download firmware upgrades for extra functions and store multiple protocols in its program memory.

Our pumps are constructed using premium materials: the rotary valve’s wetted parts are made from PCTFE (for the valve head) and PTFE (for the rotor), while the syringes are fabricated from borosilicate glass. These materials are selected for their durability and chemical resistance, ensuring that the pump can handle a wide range of chemicals without needing extra supplies or frequent refills. This robust construction makes the system cost-effective and reliable over the long term.

A low-volume rotary valve removes dead volume and minimizes internal volume to as little as 600 nL, ensuring that even the smallest amounts of fluid are accurately dispensed without cross-contamination. This design enables both infusion and withdrawal with a consistent, linear pumping rate, delivering a performance that is critical for applications requiring precise fluid handling.

The LSPone syringe pump has no dead volume, ensuring efficient fluid handling in microfluidic applications. This feature is crucial for precision in academic research, where accurate dosing and minimal waste are key. The absence of dead volume enhances the pump’s efficiency, making it a reliable tool in various scientific applications where accurate and consistent fluid control is required.

Pulseless operation, achieved in our HD models through hardware enhancements, provides smooth, continuous fluid delivery with no pressure fluctuations. This design minimizes stall and mechanical wear, ensuring that your pump operates reliably even at ultra-low flow rates. It is particularly valuable for biosensing applications where stability is paramount.

Yes, our pumps are designed for dual functionality. They can accurately infuse (push) and withdraw (pull) fluids, making them ideal for experiments that require the simultaneous addition and removal of fluids. This double capability ensures flexible and precise fluid management for a variety of experimental and scientific protocols.

Yes, our laboratory syringe pumps are designed for seamless integration with automated systems. They operate as stand-alone units with attached power supplies and USB cables while also being capable of connecting to external networks and controllers. This makes them ideal for continuous, high-throughput applications where automated, precise fluid handling is essential.

Our pumps are competitively priced to meet the needs of budget minded labs. The exact cost varies by model and configuration, factors like syringe size, flow rate, and additional features can affect the final price. For detailed pricing information, please contact our sales team. We are committed to offering an affordable yet high-performance solution that delivers maximum value without compromising on quality.

We provide comprehensive technical support, including unlimited assistance and lifetime firmware upgrades, to ensure your pump operates reliably throughout its lifespan. Our worldwide support team offers detailed documentation and troubleshooting for any voltage or mechanical issues. With a robust warranty package and continuous upgrades, our pumps are a secure, cost-effective investment for any laboratory.

They trust us

From top-tier academic institutions to pioneering biotech companies, Advanced Microfluidics is the preferred partner for innovative microfluidic solutions. Our track record of excellence and precision has earned us the trust of industry leaders, driving us to push boundaries and redefine possibilities together.

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