Launch of the new LSPone series: Precision microfluidics

Ultra low-flow rate: redefining precision

One of the major breakthroughs in our new series is the ability to achieve ultra low-flow rates. With the standard LSPone (using a 50 µL syringe), we can reach flow rates as low as 7,45 nL/min, with peak speeds of 74,5 nm/s.

This capability allows experiments that once took just a few hours to extend over several days (ranging from 10 hours to as much as 4,5 days). Such versatility is essential for applications like cell culture, where controlled, slow delivery of media or reagents is critical for maintaining optimal conditions.

While achieving such low flow rates, we also recognize that accuracy and pulse stability can be compromised. This is precisely why the LSPone HD was developed, offering a pulseless mode that guarantees continuous, stable fluid delivery without the variability often seen at such slow speeds. In fact, while traditional programmable syringe pumps typically have a coefficient of variation (CV) around 8, the LSPone HD achieves a CV of approximately 2, a major step up in stability.

The benefits of this ultra low-flow capability are clear:

• Improved flow rate control: the new edition provides enhanced control over the flow process. This means researchers and engineers can adjust fluid delivery with unmatched precision, leading to more reliable experimental results.
• Precision in data collection: many experiments demand the collection of data at minimal flow rates. With our new system, you can gather data consistently and accurately, which is vital for high-precision research in microfluidics and biological studies.
• Better control in infusion processes: for applications in biotechnology, pharmaceuticals, and medical research, controlling the fluid delivery down to extremely low flow rates ensures that treatments or experiments are performed without fluctuations or errors.

Technical details and design features

Our pumps are built with a focus on durability, versatility, and precision. Here are some key technical details that underline the quality and reliability of the new LSPone series:

Flow rate capabilities:

• With plunger speeds as low as 7,45 µm/s, the pump can achieve ultra low flow rates, reaching as low as 0,00745 µL/min.
  This level of control is essential for experiments that require extremely slow and precise fluid delivery, such as advanced cell culture or the preparation of complex reagent mixtures.

Channel diameter and internal volume:

• The channels range from 500 µm to 1000 µm in diameter.
• The unique internal geometry of the pump allows it to achieve extremely low internal volumes—down to as low as 600 nL.

These design choices not only optimize operation time but also save on costly reagents and samples, reducing the overall cost of operations.

Number of ports:

• Our rotary valve is designed with up to 12 radial ports.

This high number of ports offers the flexibility to handle multiple fluids within one device. Whether you need to manage 6 or even 12 different fluids simultaneously, our pump can accommodate your experimental requirements.

Syringe volume range:

• From 50 µL up to 5000 µL (5 mL).

With such a broad range, users can select the syringe volume that best fits their experimental needs—from small-scale laboratory experiments to larger-scale processes requiring extended fluid delivery.

Wetted materials:

• The rotary valve’s wetted parts are made of PCTFE for the valve head and PTFE for the valve rotor.
• The syringe is constructed from borosilicate glass, ensuring broad chemical compatibility and resistance to harsh environments.

This careful selection of materials guarantees that the pump can handle a wide range of chemicals, making it suitable for diverse applications—from biological samples to industrial reagents.

The power of LSPoneQuick software

A key element that sets our pumps apart is the LSPoneQuick software. designed with simplicity and speed in mind, this software allows you to unlock the full potential of your pump in just a few seconds. Here’s what makes it stand out:

• Ease of use: the software interface is intuitive and user-friendly, meaning you don’t need to be a coding expert to operate your pump. with a few clicks, you can set up and automate your fluid handling processes.
• Automation capabilities: with the integrated script editor, you can easily create custom protocols to run complex experiments automatically. This not only saves time but also minimizes the risk of human error.
• Versatility: whether you are aspirating, dispensing, mixing reagents, or running multiplex experiments, the LSPoneQuick software makes it simple to control every aspect of your pump.
• Fast setup: the plug-and-play nature of the software ensures that you can get your experiment up and running quickly, reducing downtime and boosting productivity.

The simplicity and flexibility of LSPoneQuick have been designed to meet the needs of both novice users and seasoned researchers. It is a perfect example of how we are making advanced microfluidic research accessible to everyone.

Benefits for a wide range of users

Our new LSPone series is not only for academic researchers—it is a versatile solution for startups and companies in the proof-of-concept and prototype stages. Here’s how our pumps can benefit various users:

For academic researchers:

• The LSPone and its upgraded versions provide the precision needed for cutting-edge research.
• The ease of automation and data collection ensures that experiments are both reproducible and scalable.
• The robust design means that the pump can handle a wide range of chemicals and experimental conditions.

For startups and prototype developers:

• The LSPone series allows you to quickly validate your microfluidic concepts without investing in complex, industrial-grade equipment from the start.
• The flexibility in syringe sizes—from 50 µL to 5 mL—means you can scale your experiments as your project grows.
• The intuitive LSPoneQuick software lets you automate processes early on, setting a strong foundation for later industrialization.

For industrial applications:

• The advanced features of the LSPone HD, including pulseless ultra low-flow rate operation, cater to high-demand applications in biotechnology, pharmaceuticals, and medical research.
• By transferring key innovations from the industrial programmable syringe pump (SPM) to the lab version, we ensure that your research is always one step ahead of the competition.
• The reduced footprint and optimized design mean that the pump is not only precise but also cost-effective in the long run.

The LSPone series is a true workhorse—built to support the transition from a research lab setting to an industrial production line. by focusing on both usability and precision, we are empowering users to push the boundaries of what is possible in microfluidics.

Real-life application examples

Our LSPone series makes a significant impact across a broad range of applications. In cell culture and tissue engineering, controlled delivery of nutrients and growth factors is critical. With flow rates as low as 7,45 nL/min, our pumps provide a continuous, gentle flow that closely mimics physiological conditions. In pharmaceutical testing, precise drug infusion and withdrawal are essential; the LSPone HD, with its pulseless operation, delivers exact doses over extended periods—ideal for pharmacokinetic studies. For automated reagent mixing and dilution, the LSPone series minimizes human error while ensuring reproducibility in diagnostic and analytical chemistry protocols. In microfluidic device testing and validation, our pumps offer flexible syringe volume options and controlled flow rates that allow researchers to fine-tune fluid dynamics in lab-on-a-chip systems. Additionally, the infusion systems in biotechnology benefit from our ultra-low flow capabilities, delivering even the smallest amounts of fluid with consistent accuracy.

For even more specialized requirements, our pumps excel in targeted applications such as:

• Droplets generation: Producing uniform droplets for digital PCR, single-cell analysis, and droplet-based assays;
• Protein isolation: Facilitating efficient extraction and isolation of proteins for downstream biochemical and proteomic analyses;
• Cell culture media management: Providing automated control of media delivery to maintain optimal conditions in bioreactors and culture systems;
• Continuous biosensing: Ensuring stable and consistent fluid delivery over long durations for real-time biosensing applications;
• Ion mobility spectrometry: Offering precise sample injections and controlled fluid handling for accurate ion mobility measurements;
• Immunopeptidomics: Supporting complex workflows for the extraction and processing of peptides, critical for immunopeptidomic studies;
• Sequential flow strategy: Enabling the orderly, sequential introduction of reagents and buffers—ideal for multi-step reactions and protocols;
• Nanoparticle formulation: Delivering accurate mixing and formulation to produce uniform nanoparticles with high reproducibility.

No matter your experimental needs—whether you require standard operations or specialized protocols—the LSPone series is the perfect tool. It empowers you to validate your proof of concept, transition smoothly to prototyping, and ultimately scale up to industrial production, all while delivering the precision and automation that modern scientific research demands.

Designing for the future of microfluidics

As the field of microfluidics continues to grow, so does the demand for equipment that can bridge the gap between research and industrial application. Our new LSPone series is a response to this need—combining the ease of use required in a lab setting with the robust performance necessary for industrial applications.

By focusing on practical design and real-world functionality, we are not only simplifying the process of setting up experiments but also paving the way for future innovations. Our approach of using simplified chip designs combined with complex surrounding elements, such as rotary valves and programmable syringe pumps, is revolutionizing how researchers approach fluid handling. This makes it easier to scale experiments from small, proof-of-concept studies to fully industrialized processes without losing accuracy or control.

The integration of advanced firmware innovations from our SPM into the LSPone series means that our lab tools are at the cutting edge of technology. The ultra low-flow rate edition and the high-precision HD version are perfect examples of how we continue to push the boundaries of what is achievable in microfluidics.

Discover the LSPone series advantage: the ultimate Laboratory Syringe Pump solution

We invite researchers, startups, and industry professionals to explore the new LSPone series. Whether you are looking to streamline your lab operations, validate your microfluidic prototypes, or scale up for industrial production, our pumps are designed to meet your needs.

With our new series, you no longer have to choose between ease of use and high precision. Every pump in the LSPone family is designed to adapt to your needs, ensuring that whether you are dispensing minuscule volumes or handling larger quantities, your experiments will run smoothly and accurately. Our innovative approach and commitment to quality have made the LSPone series a trusted partner in laboratories around the world.

Our team of experts is ready to help you choose the right solution for your project and to answer any questions you may have.

Embrace simplicity, reliability, and precision with the new LSPone series, because everyone needs a good pump.