Industrial Programmable Syringe Pump - SPM series | AMF
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Picto-valve-s24

from 6 ports to 12 ports valve integrated

Picto-syringe-s24

from 50 µl to 5 mL capacity

Picto-materials-s24

PTFE/PCTFE

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Distribution valve

SPM series – Industrial Programmable Syringe Pump

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    Summary

    Select options to configure the product

Introducing the SPM series – Industrial Programmable Syringe Pumps, a complete line of OEM-ready devices built for precise and reliable fluid handling. Designed for scientific, medical, and engineering environments, each model in the SPM series combines an industrial syringe pump with AMF’s high-precision low-volume rotary valve. This smart, compact system is ideal for automating complex infusion and withdrawal protocols while minimizing internal volume and sample loss. Whether you need steady flow at nanoliter scale or consistent delivery under pressure, the SPM series delivers unparalleled ease, control, and reproducibility—ready to power your next microfluidic system or instrument.

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Automated Programmable Microfluidic Syringe Pump (SPM) by AMF

The SPM series is an OEM-ready industrial programmable syringe pump line designed for automated microfluidic operations in lab and scientific settings. With a compact pumping head that minimizes the space between the syringe and AMF’s rotary valve, it achieves low volume, low carryover, and zero dead volume—making it ideal for high-precision liquid handling. Whether you need to infuse, withdraw, or perform continuous cycles, the SPM offers dual-mode operation and advanced pumping programs for full flexibility.

Built for accuracy and reliability, the system handles anything from nanoliter-scale dosing to milliliter-level dispensing, with exceptional rate accuracy and linear force control. It supports air or liquid samples, resists leakage, and features a configurable user interface with USB, TTL, and digital controller compatibility. Whether you’re working in chemistry, phd ultra-level research, or integrating into a production setup, the SPM series provides the critical features, configuration options, and programming capability to support your work with confidence.

Explore the SPM Series

The SPM series offers four distinct models, each tailored to different dosing volumes and performance requirements. Whether you’re fine-tuning microfluidic flows in early-stage R&D or deploying stable delivery profiles in industrial settings, there’s an SPM configuration built for your workflow.

SPM | P100-O

Designed for ultra-compact setups, this version supports syringe sizes from 50 µL to 1 mL, making it a solid match for low-volume applications, method development, and academic labs focused on precision.

SPM+ | P101-O

A step up in volume, this model with 2.5 mL or 5 mL syringes, giving users more flexibility for longer experiments, larger batch volumes, or systems that require higher throughput.

SPM HD | P110-O

Built for ultra-smooth operation, this version (syringe sizes from 50 µL to 1 mL) integrates a gearbox to deliver pulseless flow and excellent rate stability down to 7.17 nL/min. It’s ideal for applications where low-flow consistency is critical.

SPM+ HD | P111-O

Combining the best of both worlds, this model supports larger syringes (2.5 mL and 5 mL) while retaining the HD gearbox for exceptionally stable delivery, even at minimal flow rates.

Across the range, each SPM shares a commitment to precise fluid control, seamless integration, and high reliability, ensuring consistent performance no matter your application scale.

Standard vs HD

Both the Standard and HD variants of the SPM series share the same 30 mm plunger travel, but the HD version is designed for enhanced flow stability through significantly higher microstep resolution. The Standard models operate with 96,000 microsteps total, translating to roughly 3,200 microsteps per millimeter, while the HD models reach up to 1,296,000 microsteps, or about 43,200 microsteps per millimeter—a 13.5× increase in resolution over the same travel distance.

This improvement doesn’t change the physical step size, but it enables much smoother and more consistent flow, especially at ultra-low rates. The HD’s flow rate coefficient of variation drops from ~8 to ~2 at the lowest speeds, ensuring near-pulseless delivery even in nanoliter-per-minute regimes.

Comparative Flow Stability at 50 µL/min (5 mL Syringe)

In contrast, the Standard models can reach higher maximum flow rates, up to 150 mL/min with a 5 mL syringe, making them well-suited for faster fluid transfers. The HD models, optimized for stability over speed, cap their maximum flow rate at approximately 50 mL/min.

This trade-off allows users to select the configuration that best matches their needs: higher throughput with the Standard version or unparalleled low-flow stability with the HD.

Tailored for OEM integration – Precision by design

The SPM series is a modular OEM platform that adapts to your application—not the other way around. With a robust build and configurable architecture, it provides the flexibility you need to develop high-performance instruments at scale.

Fluidic compatibility & wetted materials

All wetted components are selected for chemical durability and biological compatibility:

  • Valve seat: PCTFE
  • Valve plug: PTFE (optional UHMW-PE)
  • Syringe barrel: Borosilicate glass
  • Syringe plunger tip: PTFE (or UHMW-PE upon request)

This configuration supports a wide range of reagents, buffers, solvents, and biological fluids without compromising reliability or sealing performance.

Internal channel diameter & carryover volume

Valve channels are available in 500 µm or 1 mm diameters. Thanks to AMF’s proprietary microfluidic geometry, internal volume can be reduced to as low as 3.6 µL, and carryover volume down to 1.5 µL (depending on valve type and port selection). This reduces reagent waste, improves cleaning efficiency, and enables faster, cleaner changeovers between samples.

Multi-port valve flexibility

With configurations ranging from 6 to 12 radial ports, the SPM’s rotary valve allows for efficient routing of multiple fluids—including samples, reagents, and air segments—across a compact footprint. Perfect for automated assays, fluid switching, or multi-step processing in a single module.

Syringe compatibility & pressure range

Available syringe volumes range from 50 µL to 5 mL, with all syringes constructed from borosilicate glass and equipped with PTFE plungers for smooth, repeatable motion. The system supports pressures up to 7 bar (102 PSI).

Wide flow rate range with HD stability

Depending on the configuration, the SPM series can deliver flow rates from 0.00717 µL/min (HD with 50 µL syringe) up to 150,000 µL/min (Standard with 5 mL syringe).

  • Standard models are optimized for maximum speed and throughput, making them ideal for faster dosing, rinsing, or flushing steps.
  • HD models feature ultra-fine microstepping (up to 1,296,000 steps per stroke), delivering near-pulseless stability at the lowest flow rates—critical for long-duration infusion, cell perfusion, or sensitive microreactor flows.

Integrated position feedback & fast switching

Each valve includes an embedded position sensor for accurate internal alignment. On startup, an automatic homing sequence ensures the rotor is correctly positioned before any flow begins.

All versions come with a fast-switching motor, capable of 400 ms port-to-port transitions, ideal for tight timing constraints in high-throughput or sequencing applications.

Modular & service-friendly design

The valve head—including the stator, rotor, and syringe—can be quickly removed and replaced for cleaning or preventive maintenance. The SPM also supports 1/4-28 UNF fluidic connectors, making it compatible with most microfluidic platforms straight out of the box.

More details

Enhance your expertise with our Application Notes, focused on microfluidic technology utilization:

Samples preparation for online liquid analysis with chemical reaction.

Microfluidic flow cytometry application for bacteria online monitoring in drinking water using BactoSense technology

 

Gain further insights with detailed guides on:

For comprehensive information, visit our technical notes page.

Discover how our SPM syringe pump is advancing research across various fields. Explore the most recent publications where the SPM’s precision and reliability have been pivotal:

Maël Arveiler, Stephanie Ognier, Olivier Venier, Laurent Schiob and Michael Tatoulian – An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures – Reaction Chemistry & Engineering – Issue 11, 2023

You can find recent publications utilizing the laboratory version of the SPM, the LSPone, showcasing the same advanced technologies and applications in microfluidics.

Xiaokang Li, Hui Song Pak, Florian Huber, Justine Michaux, Marie Taillandier-Coindard, Emma Ricart Altimiras, Michal Bassani-Sternberg – A microfluidics-enabled automated workflow of sample preparation for MS-based immunopeptidomics – Cell Reports Methods – Volume 3, Issue 6 – 2023 – 100479 – ISSN 2667-2375

Christian Thoben, Nora T. Hartner, Moritz Hitzemann, Christian-Robert Raddatz, Manuel Eckermann, Detlev Belder, and Stefan Zimmermann – Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS – Journal of the American Society for Mass Spectrometry 2023 34 (5), 857-868

Ortiz-Perez A, van Tilborg D, van der Meel R, Grisoni F, Albertazzi L. – Machine learning-guided high throughput nanoparticle design – ChemRxiv. 2023

For more comprehensive details or to explore older publications featuring our SPM, please don’t hesitate to contact us.

SPM P100-O (50 µL to 1 mL syringe size)

AMF_SPM_P100-characteristics

SPM+ P101-O (2.5 mL & 5 mL syringe size)

SPM P101-characteristics

SPM HD P110-O (50 µL to 1 mL syringe size)

AMF_SPM_HD_P110-characteristics

SPM+ HD P111-O (2.5 mL & 5 mL syringe size)

AMF_SPM+_HD_P111-characteristics

Pump specifications

Description SPM P100-O SPM+ P101-O SPM HD - P110-O SPM+ HD - P111-O
Operating temperature 15 – 45°C (59-113°F) 15-45°C (59-113°F) 15 – 45°C (59-113°F) 15 – 45°C (59-113°F)
Operating humidity 20-80%, non condensing 20-80%, non-condensing 20-80%, non condensing 20-80%, non condensing
Max. pressure 7 bars (102 psi) 7 bars (102 psi) 7 bars (102 psi) 7 bars (102 psi)
Wetted materials PTFE or UHMW-PE, PCTFE and borosilicate glass PTFE or UHMW-PE, PCTFE and borosilicate glass PTFE or UHMW-PE, PCTFE and borosilicate glass PTFE or UHMW-PE, PCTFE and borosilicate glass
Syringe size capacity From 50 µL to 1 mL 2.5 mL & 5 mL From 50 µL to 1 mL 2.5 mL & 5 mL
Dead volume None None None None
Carryover volume (configuration dependent) 1.5 – 8 μL 13.4 – 18.6 μL 1.5 – 8 μL 13.4 – 18.6 μL
Plunger travel 30 mm with 96,000 micro-steps 30 mm with 96,000 micro-steps 30 mm with 1'296'000 micro-steps 30 mm with 1'296'000 micro-steps
Plunger resolution Selectable 3,000 steps (standard) / 24,000 steps (high) Selectable 3,000 steps (standard) / 24,000 steps (high) Selectable 3,000 steps (standard) / 24,000 steps (high) Selectable 3,000 steps (standard) / 24,000 steps (high)
Plunger drive Screw drive with linear encoder for step loss detection Screw drive with linear encoder for step loss detection Screw drive with linear encoder for step loss detection Screw drive with linear encoder for step loss detection
Valves configuration Zero-dead-volume multi-port distribution with angular encoder Zero-dead-volume multi-port distribution with angular encoder Zero-dead-volume multi-port distribution with angular encoder Zero-dead-volume multi-port distribution with angular encoder
Tube port fittings Standard 1/4 – 28 UNF, flat-bottom Standard 1/4 – 28 UNF, flat-bottom Standard 1/4 – 28 UNF, flat-bottom Standard 1/4 – 28 UNF, flat-bottom
Cross-contamination Typically from 1/100 to 1/1000 per cleaning cycle Typically from 1/100 to 1/1000 per cleaning cycle Typically from 1/100 to 1/1000 per cleaning cycle Typically from 1/100 to 1/1000 per cleaning cycle
Accuracy < 1% deviation from expected value at full stroke < 1% deviation from expected value at full stroke < 1% deviation from expected value at full stroke < 1% deviation from expected value at full stroke
Electrical interface USB mini, 9–pin D–Sub (other upon request) USB mini, 9–pin D–Sub (other upon request) USB mini, 9–pin D–Sub (other upon request) USB mini, 9–pin D–Sub (other upon request)
Interface USB mini, RS-232, RS-485 USB mini, RS-232, RS-485 USB mini, RS-232, RS-485 USB mini, RS-232, RS-485
Communication type Serial (serial over USB, RS-232, RS-485) Serial (serial over USB, RS-232, RS-485) Serial (serial over USB, RS232, RS485) Serial (serial over USB, RS232, RS485)
Power 18 VDC, 2.2 A peak, 40 W (18 VDC optimized for battery use) 18 VDC, 2.2 A peak, 40 W (18 VDC optimized for battery use) 18 - 24 VDC, 2.2 A peak, 40 W / 18 VDC optimized for battery use 18 - 24 VDC, 2.2 A peak, 40 W / 18 VDC optimized for battery use
Time for full stroke 2 to 6000 seconds 2 to 6000 seconds 2 to 6000 seconds 2 to 6000 seconds
Dimensions 199.7 x 126.3 x 50.5 mm 211.9 x 136.7 x 49.6 mm 199.7 x 126.3 x 50.5 mm 211.9 x 136.7 x 49.6 mm
Weight 1.5 kg 1.6 kg 1.5kg 1.6 kg

Valve specifications for SPM P100-O & SPM HD P110-O - (50 µL to 1 mL syringe size)

Ref. Configuration Wetted materials Internal volume Carryover volume Fluid path diameter Max. pressure
V–D–2–6–050–C–P 6 ports ultra-low carryover volume PCTFE, PTFE 5.2 μL 1.5 μL 0.5 mm 7 bars
V–D–1–6–050–C–P 6 ports low carryover volume PCTFE, PTFE 3.6 μL 2.6 μL 0.5 mm 7 bars
V–D–1–8–050–C–P 8 ports low carryover volume PCTFE, PTFE 3.6 μL 2.6 μL 0.5 mm 7 bars
V–D–1–8–100–C–P 8 ports low carryover volume PCTFE, PTFE 15 μL 8 μL 1 mm 7 bars
V–D–1–10–050–C–P 10 ports low carryover volume PCTFE, PTFE 4.6 μL 2.8 μL 0.5 mm 7 bars
V–D–1–10–100–C–P 10 ports low carryover volume PCTFE, PTFE 15 μL 8 μL 1 mm 7 bars
V–D–1–12–050–C–P 12 ports low carryover volume PCTFE, PTFE 4.6 μL 2.8 μL 0.5 mm 7 bars

Valve specifications for SPM+ P101-O & SPM+ HD P111-O (2.5 mL & 5 mL syringe size)

Ref. Configuration Wetted materials Internal volume Carryover volume Fluid path diameter Max. pressure
V-D-1-6-050-C-P 6 ports low carryover volume PCTFE, PTFE 14.4 µL 13.4 μL 0.5 mm 7 bars
V-D-1-10-050-C-P 10 ports low carryover volume PCTFE, PTFE 15.4 µL 13.6 μL 0.5 mm 7 bars
V-D-1-10-100-C-P 10 ports low carryover volume PCTFE, PTFE 25.7 µL 18.6 μL 1 mm 7 bars
V-D-1-12-050-C-P 12 ports low carryover volume PCTFE, PTFE 15.4 μL 13.6 μL 0.5 mm 7 bars

Valve heads are interchangeable. Other models and customs available upon request.

Syringe specifications for SPM P100-O

Reference Volume Plunger material Min. flow rate Max. flow rate Min. dosing volume
S–50–P 50 μL PTFE 0.00745 μL/min 1 500 μL/min 0.1 μL
S–100–P 100 μL PTFE 0.0149 μL/min 3 000 μL/min 0.2 μL
S–100–U 100 μL UHMW-PE 0.0149 μL/min 3 000 μL/min 0.2 μL
S–250–P 250 μL PTFE 0.0373 μL/min 8 000 μL/min 0.5 μL
S–500–P 500 μL PTFE 0.0745 μL/min 14 000 μL/min 1 μL
S–500–U 500 μL UHMW-PE 0.0745 μL/min 14 000 μL/min 1 μL
S–1000–P 1 000 μL PTFE 0.149 μL/min 30 000 μL/min 2 μL

Syringe specifications for SPM HD P110-O

Reference Volume Plunger material Min. flow rate Max. flow rate Min. dosing volume
S–50–P 50 μL PTFE 0.00717 μL/min 500 μL/min 0.1 μL
S–100–P 100 μL PTFE 0.0144 μL/min 1 000 μL/min 0.2 μL
S–100–U 100 μL UHMW-PE 0.0144 μL/min 1 000 μL/min 0.2 μL
S–250–P 250 μL PTFE 0.0359 μL/min 2 500 μL/min 0.5 μL
S–500–P 500 μL PTFE 0.0717 μL/min 5 000 μL/min 1 μL
S–500–U 500 μL UHMW-PE 0.0717 μL/min 5 000 μL/min 1 μL
S–1000–P 1 000 μL PTFE 0.143 μL/min 10 000 μL/min 2 μL

Syringe specifications for SPM+ P101-O

Reference Volume Plunger material Min. flow rate Max. flow rate Min. dosing volume
S–2500–P 2 500 μL PTFE 0.0373 μL/min 75 000 μL/min 5 μL
S–5000–P 5 000 μL PTFE 0.0745 μL/min 150 000 μL/min 10 μL

Syringe specifications for SPM+ HD P111-O

Reference Volume Plunger material Min. flow rate Max. flow rate Min. dosing volume
S–2500–P 2 500 μL PTFE 0.0359 μL/min 25 000 μL/min 5 μL
S–5000–P 5 000 μL PTFE 0.0717 μL/min 50 000 μL/min 10 μL

Chemical compatibility: The wetted materials being PTFE, PCTFE and borosilicate glass, this pump offers an exceptional compatibility to most chemicals and biological samples.

The above specifications are typical for our components and may vary due to multiple parameters / factors (e.g. fluid type, usage conditions…). Specifications are subject to change.

Optional:
It is possible to add a heating/cooling module around the syringe to suit your specific application.

AMF-Part_names_specifications_wb

SPM Microdispenser enhances setup precision and robustness

Théo Mayer - EPFL Master Student EPFL

AMF’s products automate microfluidics with precise control and timely support

Xiaokang LI - Postdoctoral researcher Department of Oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne Centre de recherche Agora

AMF valves meet our needs, particularly in terms of control

Bernard Roux - Lab manager Solvay

AMF’s compact products and expert support boost microfluidics

Hana Samet - Engineer AGORA & EPFL Research Center

We are highly content with our AMF rotary valves’ performance

Maarten Jorna - Mechanical engineer The Sensor Factory

Custom AMF components allowed us to develop the first online flow cytometer for water monitoring

Simon Kuenzi - CEO bNovate

AMF valves, delicately designed, reflect Swiss precision

Yujing Song - PhD Michigan Univeristy

FAQs: Navigating the SPM - Industrial Programmable Syringe Pump

Welcome to our detailed FAQ section, built to enhance your understanding of the SPM – Industrial Programmable Syringe Pump.

The SPM Series by AMF is a family of industrial programmable syringe pumps built for integration into automated instruments and microfluidic devices. It’s ideal for laboratories, R&D platforms, and OEM applications that demand high precision, low volume handling, and robust fluid control.

Unlike peristaltic pumps, which are best for bulk fluid movement, the SPM offers precise dispensing, low internal volume, and programmable sequences for nano- to milliliter volumes. It’s optimized for repeatability, flow-rate stability, and clean transitions—key for scientific processes requiring accuracy.

Both offer a 30 mm plunger travel, but HD models feature higher step resolution (up to 1,296,000 microsteps), providing smoother, pulseless flow for ultra-low rates. The Standard versions support faster operation with flow rates up to 150 mL/min, while HD models are capped at 50 mL/min for enhanced flow stability.

The SPM series supports borosilicate glass syringes from 50 µL to 5 mL. Standard & HD variants handle up to 1 mL; SPM+ models extend to 5 mL, covering both low-volume and high-throughput needs.

With the HD configuration and a 50 µL syringe, the minimum flow rate can reach 0.00717 µL/min, making it suitable for highly controlled, long-duration infusion or low-volume dosing.

Yes, the SPM is fully OEM-customizable—including syringe size, valve type, port count (6–12), and communication interface. It’s compatible with standard 1/4-28 UNF connectors and supports USB, RS-232, and RS-485 for integration into larger automated systems.

Absolutely. The valve head kit (stator, rotor, and syringe) is modular and can be quickly replaced or cleaned. Preventive maintenance is simple and tool-free, minimizing downtime and ensuring reliable performance over time.

Thanks to PTFE, PCTFE, borosilicate glass, and EPDM seals, the SPM is compatible with a wide range of aqueous, organic, and biological fluids, including reagents and solvents commonly used in chemistry, diagnostics, and life sciences.

The SPM is programmable via serial commands and supports TTL, RS232/RS485, and USB communication. While it doesn’t include dedicated touchscreen software, users can control it via Python, MATLAB, or LabVIEW using our documentation and command set.

The SPM is ideal for automated dispensing, sample prep, reagent mixing, cell perfusion, and any process requiring precision and repeatability—whether in analytical labs, point-of-care systems, or scientific legato-type workflows.

Programmable syringe pumps like the SPM offer:

  • High precision control
  • Advanced programming via command scripting
  • Adjustable pumping rate
  • Support for continuous, infuse, and withdraw modes

Integration flexibility through USB, TTL, RS232 or RS485.
These pumps automate complex lab processes with unparalleled ease.

Key factors include:

  • Required minimum flow rate (as low as 0.00717 µL/min for SPM HD)
  • Syringe volume (from 50 µL to 5 mL)
  • Desired flow stability vs. maximum speed
  • Chemical compatibility of wetted materials
  • Interface and cable type (USB, TTL, serial)
    The SPM line provides versatile configurations for all use cases.

Syringe pumps work by controlled push-pull movement of a motor-driven plunger. The movement controls the volume dispensed or withdrawn, delivering precise amounts of fluid in a highly controlled, reproducible manner.

Key benefits include:

  • Customized fluid handling profiles
  • Reduced manual errors via automation
  • Versatile operation for various lab workflows
  • Intelligent command control

Compatibility with external software platforms
These pumps are ideal for any lab requiring consistent, cost-efficient fluid control.

Programming is done via serial commands using Python, MatLab, LabVIEW, or a terminal interface. You can set parameters, create custom sequences, and run loops for automated processes. The SPM supports two step resolutions: 3,000 or 24,000 steps per stroke.

Refer to the datasheets for:

  • Syringe sizes
  • Minimum/maximum flow rate
  • Voltage (18–24 VDC) and power rating (40 W)
  • Weight: ~1.5 kg
  • Dimensions
  • Wetted materials, internal volume, and carryover volume
  • Warranty and RoHS compliance

Yes. The SPM supports continuous flow, multi-step dosing, and looped operation for applications like microfluidic perfusion, gradient generation, and high-throughput screening.

The system is rated for up to 7 bar (102 PSI), making it suitable for pressurized systems. The materials and seals ensure leak-free performance even under demanding fluidic conditions.

Yes. While optimized for OEM integration, the SPM can also be used in manual workflows with simple command-line control, offering precision and versatility without complex infrastructure.

The SPM combines:

  • Customizability
  • High durability
  • Minimal carryover volume
    This reduces reagent loss, cleaning effort, and integration time—making it a cost-effective, lab-ready product for demanding microfluidic applications.

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