Microfluidic Distribution Valves: applications and customization
AMF-Microfluidic_Distribution_Valve_1
Oct 2024

What is a microfluidic distribution rotary valve? Key features and benefits

Microfluidic rotary valves are essential components in modern fluidic systems, offering precise control over the flow of liquids through multiple channels. Microfluidic distribution valves are designed to enable efficient routing of liquids between pathways, allowing the sequential delivery of fluids in applications ranging from chemical analysis to biological experiments. Their ability to manage liquid flow with minimal internal volume and low dead volume makes them ideal for processes that require high precision.

In the world of microfluidic devices, rotary valves are the gatekeepers for directing and regulating the flow of fluids. The microfluidic distribution rotary valve, in particular, plays a critical role in the automation of fluidic processes.

How microfluidic distribution valves drive precision flow control?

Microfluidic distribution valves are designed to direct fluids through various pathways with incredible accuracy, ensuring optimal performance across diverse applications. These valves enable automation in fluid handling, providing a tool that allows for the precise injection and control of liquids within laboratory and industrial instruments. This precision is essential in fields such as biology, chemistry, and diagnostic testing, where the timing and regulation of fluid movement are critical.

AMF’s standard microfluidic distribution rotary valves are available in configurations ranging from 6 to 24 ports. These designs feature one axial port entry on the front and up to 24 radial ports. Customization options allow for configurations with fewer than 6 or more than 24 ports, catering to specific project requirements.

AMF-Microfluidic_Distribution_Valve_2
The core functionality of these valves lies in their ability to route fluids into multiple streams, enabling the sequential injection of different liquids into a system. This is achieved through the combined action of a motor and a precisely calibrated rotor, which acts as a switching mechanism to direct fluid flow along predefined pathways.

AMF-Microfluidic_Distribution_Valve_3
In the visual, we illustrate the key components of the valve, including the stator, rotor, and connectors. Fluid 1 enters through a radial port and exits via the axial port. The rotor then rotates to allow Fluid 2 to enter through a different radial port and exit through the same axial port, demonstrating how the valve manages fluid switching in a controlled, sequential manner.

This process ensures that each fluid is routed precisely, supporting a wide variety of applications that demand accurate fluid control.

The unmatched advantages of AMF’s microfluidic distribution valves

AMF’s microfluidic distribution valves are crafted with precision and efficiency at their core, providing unparalleled versatility and adaptability across a broad range of applications. 

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Demonstration model in PMMA, showcasing precision engineering
One of the key benefits of these valves is the exceptional quality of production, which results in the following advantages:

  • Low internal volume
  • Zero dead volume
  • Minimal carryover volume
  • Reduced risk of contamination

AMF-Microfluidic_Distribution_Valve_5
Demonstration model in PMMA, showcasing precision engineering
What truly sets AMF’s microfluidic distribution rotary valves apart from competitors is their adaptability to different sizes and flow requirements. This makes them ideal for both small-scale laboratory experiments and large industrial processes.

Users can easily adjust the valves for various flow rates and sequences, ensuring accurate results and optimal process efficiency in any setup. Additionally, AMF thoroughly evaluates each project to determine the best material for the application. Whether it’s PEEK, PTFE, PCTFE, or UHMW–PE, we offer the widest range of material options for microfluidic distribution rotary valves.

These valves seamlessly integrate into microfluidic systems, ensuring smooth fluid management while minimizing flow rate variations and providing precise flow measurement, making them an essential tool for any fluidic process.

Key specifications of AMF’s microfluidic distribution valves

AMF’s microfluidic distribution valves are designed to meet the rigorous demands of a wide range of applications, from lab-on-a-chip systems to high-throughput industrial processes. Their adaptability and high performance stem from specific design features that optimize fluid management under diverse conditions.

To make it easier to understand our product offerings, here is a breakdown of the nomenclature used for our valves:

V-A-B-C-D-E-F (e.g. V-D-1-5-050-C-P)

  • V = Valve
  • A = Type (D = Distribution, O = On/Off, S = Switch)
  • B = Number of stages
  • C = Number of radial ports
  • D = Diameter of the channels (e.g. 0.5 mm = 050, 1 mm = 100)
  • E = Stator material (PCTFE = C, PEEK = K)
  • F = Rotor material (PTFE = P, UHMW-PE = U)

Now that you’re familiar with our coding system, here are some specific configurations and their performance details:

Ref. Configuration Wetted Materials Internal Volume Carryover Volume Fluid Path Diameter Max. Pressure
V–D–1–6–050–C–P 6 ports, low carryover PCTFE, PTFE 2.5 μL 1.5 μL 0.5 mm 7 bars
V–D–1–8–050–C–P 8 ports, low carryover PCTFE, PTFE 2.5 μL 1.5 μL 0.5 mm 7 bars
V–D–1–8–100–C–P or U 8 ports, low carryover PCTFE, PTFE or UHMW–PE 13.8 μL 6.7 μL 1 mm 7 bars
V–D–1–10–050–C–P or U 10 ports, low carryover PCTFE, PTFE or UHMW–PE 3.5 μL 1.7 μL 0.5 mm 7 bars
V–D–1–10–100–C–P or U 10 ports, low carryover PCTFE, PTFE or UHMW–PE 13.8 μL 6.7 μL 1 mm 7 bars
V–D–1–12–050–C–P or U 12 ports, low carryover PCTFE, PTFE or UHMW–PE 3.5 μL 1.7 μL 0.5 mm 7 bars
V–D–2–24–050–K–P 24 ports, low carryover PEEK, PTFE 3.6 μL 2.2 μL 0.5 mm 7 bars

The above specifications are typical for our components and may vary due to multiple parameters / factors (e.g. fluid type, usage conditions…). Specifications are subject to change.
These references offer flexibility across various applications, ensuring that AMF valves fit your exact project needs with the reliability and performance. Whether you require low carryover volume for sensitive biological applications or higher port counts for complex industrial setups, our valves provide the optimal solution for precision fluid management.

Seamless integration with AMF systems: RVM, SPM, and LSPone

AMF’s microfluidic distribution valves are designed for easy and seamless integration with our core systems: the RVM Industrial Microfluidic Rotary Valve, the SPM Industrial Programmable Syringe Pump, and the LSPone Laboratory Programmable Syringe Pump. Each of these components is engineered to work harmoniously with our valves, offering users a streamlined experience in both installation and operation.

RVM Industrial Microfluidic Rotary Valve

AMF-Microfluidic_Distribution_Valve-RVM
The RVM Industrial Microfluidic Rotary Valve is ideal for high-precision fluid switching, making it ideal for applications requiring complex multi-pathway fluid routing. AMF’s distribution valves connect effortlessly to the RVM, allowing users to automate intricate fluid distribution tasks with minimal manual intervention. This integration significantly reduces downtime and improves the overall efficiency of the system.

Example of use of a microfluidic distribution rotary valve with the RVM:

Maël Arveiler, Stephanie Ognier, Olivier Venier, Laurent Schiob and Michael Tatoulian – An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures – Reaction Chemistry & Engineering – Issue 11, 2023

SPM Industrial Programmable Syringe Pump

AMF_SPM_P101-O_1-min
The SPM Industrial Programmable Syringe Pump is a highly versatile component designed for precise fluid dispensing and distribution, particularly in OEM applications. When combined with AMF’s microfluidic distribution valves, the SPM creates a flexible platform capable of automated ultra-low volume dispensing with remarkable accuracy. Unlike conventional systems, the unique pairing of the SPM with our valves minimizes carryover volume to an exceptional degree, making it ideal for applications where precise fluid measurement and minimal cross-contamination are crucial.

VISUAL

This integration ensures that even the smallest volumes are dispensed accurately, which is critical in industries such as pharmaceuticals, biotechnology, and chemical processing, where precise liquid handling is essential for product consistency and experimental accuracy.

Example of use of a microfluidic distribution rotary valve with an SPM:

Maël Arveiler, Stephanie Ognier, Olivier Venier, Laurent Schiob and Michael Tatoulian – An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures – Reaction Chemistry & Engineering – Issue 11, 2023

LSPone Laboratory Programmable Syringe Pump

AMF_LSPone_P100-L_1-min
Finally, the LSPone Laboratory Programmable Syringe Pump is designed for handling multiple fluids simultaneously, making it the ideal companion for AMF’s microfluidic distribution valves. When integrated with the LSPone, these valves enable the system to efficiently manage and automate complex multi-fluid applications, such as multi-reagent experiments, with precision and ease. The ability to quickly switch between different fluid paths enhances both the accuracy and efficiency of fluid management, ensuring optimal performance in demanding laboratory environments.

The flexibility of the LSPone system, combined with AMF’s valves, makes it the perfect solution for customized microfluidic applications. Whether it’s for research or industrial production, the LSPone system ensures seamless, automated fluid handling, improving workflow consistency and reducing the risk of human error.

Example of use of a microfluidic distribution rotary valve with a LSPone:

Xiaokang Li, Hui Song Pak, Florian Huber, Justine Michaux, Marie Taillandier-Coindard, Emma Ricart Altimiras, Michal Bassani-Sternberg – A microfluidics-enabled automated workflow of sample preparation for MS-based immunopeptidomics – Cell Reports Methods – Volume 3, Issue 6 – 2023 – 100479 – ISSN 2667-2375

Maël Arveiler, Stephanie Ognier, Olivier Venier, Laurent Schiob and Michael Tatoulian – An innovative sequential flow platform for automated multi-step chemical processes – proof of concept with the separation of amine/alkene model mixtures – Reaction Chemistry & Engineering – Issue 11, 2023

Christian Thoben, Nora T. Hartner, Moritz Hitzemann, Christian-Robert Raddatz, Manuel Eckermann, Detlev Belder, and Stefan Zimmermann – Regarding the Influence of Additives and Additional Plasma-Induced Chemical Ionization on Adduct Formation in ESI/IMS/MS – Journal of the American Society for Mass Spectrometry 2023 34 (5), 857-868

Ortiz-Perez A, van Tilborg D, van der Meel R, Grisoni F, Albertazzi L. – Machine learning-guided high throughput nanoparticle design – ChemRxiv. 2023

Tailored solutions: customization options for specific needs

AMF understands that every application is unique, and off-the-shelf solutions may not always meet specific requirements. That’s why we offer a range of customization options for our microfluidic distribution valves to ensure they fit perfectly into your setup, no matter the complexity of your project. 

We collaborate closely with our customers to adapt our valves to different needs, from adjusting port configurations to selecting the ideal materials for enhanced chemical compatibility. Whether you are working in pharmaceuticals, biotechnology, or industrial production, AMF’s flexible customization ensures that you get the most efficient and effective solution.

One example of our tailored solution is the custom distribution switch component developed for a customer requiring fast, accurate fluid switching across multiple pathways. This solution featured a custom valve that combines fluid distribution and switching capabilities in one compact unit, reducing system complexity and allowing for more efficient sample handling.

Another example is a custom complex nanoparticle generator system designed to produce high-quality particles for biomedical research. This project utilized a 24-port distribution valve, which allowed for precise control over multiple fluid inputs, ensuring consistent and reproducible nanoparticle synthesis. By integrating our  valve, the system achieved high accuracy and minimal cross-contamination, delivering superior results in the production of nanoparticles.

By offering these options, AMF can develop a solution that perfectly matches your project’s demands. Our engineering team works closely with you to assess your needs and design a valve that enhances your system’s efficiency, performance, and reliability.

Real-world applications of microfluidic distribution valves

Microfluidic distribution valves are fundamental components in the precise management of fluid pathways across various scientific and industrial applications. Their ability to control and route multiple fluid streams efficiently has revolutionized fields such as diagnostics, pharmaceuticals, environmental monitoring, and chemical processing. Whether integrated into compact lab-on-a-chip systems or large-scale instrumentation, these valves enable real-time fluid handling with unparalleled precision.

  • Lab-on-a-chip and organ-on-a-chip systems: Essential for routing fluid streams and managing complex experimental sequences with high reproducibility, enabling precise mimicry of cellular environments in biological assays.
  • Diagnostic instruments: Manage sequential injections of samples and reagents, minimizing cross-contamination and ensuring accurate data output in real-time testing.
  • Pharmaceutical industry: Support high-throughput screening and drug development by handling multiple fluid pathways and enabling simultaneous, efficient testing of drugs and reagents.
  • Chemical process control: Useful for flow chemistry and synthetic chemistry, these valves enable controlled, repeatable injection and mixing of reagents, optimizing reaction conditions in real-time.
  • Environmental and asset monitoring: Ensure accurate, sequential sampling for chemical level tracking and fluid analysis, often paired with flow metering and pressure management systems.
  • Microscopy applications: Facilitate precise fluid delivery for imaging experiments, enabling the detailed study of biological processes, drug interactions, and cellular behavior.

Microfluidic distribution valves offer critical functionality across numerous real-world applications, ensuring efficient, accurate, and controlled fluid management. 

Final thoughts on optimizing fluidic management with AMF valves

AMF’s microfluidic valves are not just components; they are integral tools for optimizing fluidic management across a wide range of applications. The flexibility, reliability, and efficiency of our valves can dramatically enhance the performance of your systems.

Our valves within our components (RVM or SPM) are designed to seamlessly integrate into existing platforms, allowing for rapid deployment and easy maintenance. From custom port configurations to durable material options, AMF offers tailored solutions that meet the specific needs of each project. By minimizing downtime, reducing fluid waste, and enabling precise control, our valves provide long-term value and support for your evolving applications.

Optimizing your fluidic management with AMF valves means you’ll benefit from:

  • Precise fluid control: For accurate handling of small volumes and complex multi-reagent setups.
  • Easy integration: Compatible with a range of AMF components like the RVM, SPM, and LSPone.
  • Customization: Solutions tailored specifically for your application’s unique requirements.
  • Durability and reliability: Built to withstand harsh conditions and maintain consistent performance over time.

To explore how AMF can help you optimize fluidic management for your project, please fill out the form below to get in touch with our team. We are eager to discuss your specific needs and provide detailed information on how our valves can improve your fluid handling systems.

Please fill the form and one of our experts will get back to you with details.

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