In advanced microfluidic workflows, stability at ultra-low flow rates is no longer a luxury. From single-cell biology to continuous perfusion, organ-on-chips models and droplet microfluidics, many applications now demand precise, pulseless delivery in the nanoliter-per-minute range. Traditional syringe pumps, while easy to implement, often hit their limits at these extremes, struggling with flow instability, pulsing effects, inconsistent accuracy, or maintenance complications.
That’s why we developed the LSPone HD.
This new version of our trusted LSPone platform is designed specifically to overcome the pain points engineers and scientists regularly encounter when working at the frontier of flow control. While syringe pumps are sometimes criticized for poor stability or limited low-end performance, especially when compared to pressure-based systems, the LSPone HD changes the game.
The LSPone HD delivers a 13.5× increase in control granularity, enabling unparalleled smoothness and flow consistency, without altering the size, usability, or software interface of the original device. The result? A programmable, plug-and-play syringe pump that delivers clean, stable, and accurate flow at rates previously thought impractical for syringe-based systems.
Whether you’re developing a proof of concept in a startup lab or running a high-sensitivity microfluidic assay in an academic or R&D setting, the LSPone HD offers a solution that scales with your needs. It bridges the performance gap between traditional pumps and complex flow control systems, making high-precision, ultra-low flow delivery accessible right from your bench.
The LSPone series is more than just a lab syringe pump, it’s a compact, scalable, and automation-ready solution for anyone working with microfluidics. Designed with versatility in mind, the LSPone serves as a reliable bridge between early-stage experimentation and full system integration.
At its core, the LSPone is a bench-top, plug-and-play syringe pump. It’s designed to get you up and running in minutes, not hours. Whether you’re an academic researcher, a startup prototyping your first microfluidic system, or a product team validating a new bioassay, the LSPone offers a fast, precise way to control fluids with minimal setup.
But this is not just another basic syringe pump.
What sets the LSPone apart is its integrated, high-precision bidirectional flow control, powered by a programmable stepper motor and supported by intuitive software, LSPoneQuick. This user-friendly graphical interface allows you to run and automate complex liquid handling protocols with no need for coding. For more advanced users, Python scripting and LabVIEW integration are also supported.
In addition, the LSPone is equipped with a rotary valve, available in 6 to 12 ports. This transforms the system into a fully programmable liquid handling platform capable of:
All of this is built around robust fluidic engineering: low internal volume, no dead volume, and ultra-low carryover, key features when dealing with precious reagents, biological samples, or contamination-sensitive workflows.
The LSPone series is available in multiple versions:
The new LSPone series includes:
Extremely versatile and efficient across a wide range of applications, including high flow rates up to 150 mL/min
Designed for extreme flow stability and pulseless delivery at ultra-low flow rates in the nanoliter-per-minute range
No matter your scale or complexity, the LSPone is built to grow with your needs—from early R&D to automated workflows. And with its compact footprint and quiet operation, it fits seamlessly on any lab bench.
The LSPone is your gateway to precision microfluidics—no barriers, no compromises.
At first glance, the LSPone HD looks just like any other member of the LSPone family. Same size, same interface, same software. But inside, there’s a major difference: an upgrade that drastically improves the pump’s ability to operate at ultra-low flow rates with exceptional stability.
Why does this matter? In microfluidics, small variations in flow can create big problems. Instability, pulsing, or even micro-bursts can disrupt cell cultures, compromise droplet formation, or introduce noise into precision assays. That’s where the LSPone HD shines.
By increasing the number of discrete motion steps, the HD version provides:
Real-world testing has shown that at flow rates at nanoscale, the LSPone HD can operate continuously for multiple days with real stability. All of this without the need for external dampers, feedback systems, or complex tuning.
This isn’t just a spec sheet upgrade, it’s a performance shift that makes the LSPone HD a serious alternative to high-end pressure controllers in low-flow applications.
On the other hand, the Standard model supports faster operation, reaching flow rates up to 150 mL/min with a 5 mL syringe. The HD version, optimized for control rather than speed, has a maximum flow rate of 50 mL/min.
Microfluidic applications often push the boundaries of precision, especially when it comes to flow control. Whether you’re culturing cells over days, generating droplets, or handling rare reagents, even the smallest fluctuation in flow can impact results. That’s where the LSPone HD sets itself apart.
This pump was designed to thrive in the most demanding conditions, and its performance at the lowest flow rates proves it. We tested the LSPone HD across a wide range of syringe sizes and flow conditions to understand how far we could push it, and the results speak for themselves.
To help users visualize these performance gains, we created flow rate CV heatmaps comparing the standard LSPone and the HD version. These maps show the optimal operational range for each pump:
The standard LSPone reaches higher maximum flow rates, making it ideal for general-purpose tasks.
The LSPone HD, on the other hand, dominates in the ultra-low, high-stability region, exactly where flow consistency matters most.
This precision makes the HD version especially suited for sensitive applications like continuous perfusion, droplet generation, and gradient formation, where stable low flow is a must.
So if you’ve ever struggled with fluctuations at low speed, or had to compensate for unstable syringe pumps using feedback loops or extra hardware, the LSPone HD offers a cleaner, simpler solution. It delivers microfluidic-grade performance in a plug-and-play package.
When consistent flow is critical, and the smallest volumes matter most, the LSPone HD gives you full control, no compromises, no interruptions.
Microfluidic systems rely on precise, stable flow control, but not all pump technologies are built for the demands of modern applications. To help you navigate the options, we’ve benchmarked the LSPone HD against other widely used technologies: pressure controllers, standard laboratory syringe pumps, and entry-level OEM syringe modules.
A quick breakdown:
Pressure controllers are often praised for their fast response times and smooth delivery at low flow rates, but there’s an important nuance. These systems rely heavily on external flow rate sensors to function. And those sensors come with limits: most are calibrated only for standard fluids like water and IPA, which means their performance can degrade significantly when used with custom buffers, biological reagents, or solvents. Additionally, they have a minimum detectable flow increment, below which they cannot reliably push liquid. For ultra-low or continuous nanoliter delivery, this can become a hard barrier.
By contrast, the LSPone HD operates on direct, constant-volume actuation. There’s no dependency on fluid properties or sensor calibration, the system accurately dispenses what you tell it to, regardless of the liquid type. Whether it’s aqueous, viscous, organic, or biological, you get consistent, pulseless flow every time.
Basic syringe pumps, on the other hand, are often attractive for early prototyping. But they fall short when stability, smoothness, or true microfluidic control is required. Their motor resolution and control electronics weren’t designed for high-precision applications, and it shows in their fluctuating CVs and poor reproducibility below the microliter-per-minute range.
The LSPone HD bridges that gap. With ultra-high microstepping resolution, clean push-pull actuation, and native compatibility with up to 12-port valves, it delivers pressure-like flow quality without the limitations of pressure systems. You don’t need to worry about fluid-specific calibration, sensor feedback, or minimum actuation thresholds. You just set the volume and let the system do the work.
To make this performance difference crystal clear, here is a graph comparing flow stability (CV%) across various flow rates for three platforms: LSPone HD, a leading pressure controller, and a basic syringe pump. The results confirm what we’ve seen in practice, the HD version consistently delivers smooth, stable flow, even where the other systems begin to show drift or variation.
The LSPone HD isn’t made for everyone. It’s made for those who need absolute precision at ultra-low flow rates—without the instability, pulsing, or workarounds that come with standard syringe pumps.
If your work depends on steady, reproducible flow over hours or even days, or if you’re operating at the frontiers of biology, chemistry, or diagnostics, the LSPone HD was built for you.
Here are just a few of the domains where the LSPone HD shines:
These micro-physiological models often require long-term, low-shear perfusion to maintain tissue viability and mimic real physiological conditions. The LSPone HD delivers exactly that—without the need for external dampers or complex flow regulation systems.
In droplet generation and manipulation, consistency is key. Any flow variation can result in unstable droplet sizes or frequencies. The HD’s ultra-smooth flow ensures reliable droplet formation—even at nanoliter-per-minute rates.
When working with rare samples or reagents that must be delivered with extreme accuracy and minimal loss, the HD version offers low carryover and clean fluid handling, ensuring each step of the protocol is tightly controlled.
Delivering reagents to or extracting fluids from single cells requires flow control that’s not just precise, but stable enough to avoid disrupting delicate biological processes. The LSPone HD offers near-pulseless delivery, making it ideal for these highly sensitive operations.
Some experiments run for days. Others involve maintaining flow conditions through temperature or pressure changes. The LSPone HD is designed to stay stable under these conditions, giving you the confidence that your flow won’t drift or pulse over time.
No matter your application, if you’re pushing the limits of flow stability and precision, the LSPone HD is a smart, scalable alternative to pressure controllers and low-end syringe pumps alike.
It’s built for labs, startups, and research teams that can’t afford errors—and need a system that just works, every time.
With the LSPone HD, ultra-low flow rate performance is no longer reserved for complex or expensive setups. You get the stability and precision of high-end flow control systems.
It’s still the same LSPone you know: compact, quiet, plug-and-play, and fully programmable. But now with enhanced mechanical resolution, the HD version brings smooth, pulseless delivery at flow rates once considered out of reach for syringe pumps.
Whether you’re working in droplet microfluidics, organ-on-chip systems, or long-term perfusion experiments, the LSPone HD helps you push the boundaries of what’s possible.
Ready to explore what the LSPone HD can do for your project?
Whether you’re looking for pricing, technical details, or a live demonstration, we’re here to help. Fill out the short form below and our team will get back to you as soon as possible.
Let’s build something precise, together.
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